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Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 784-798 doi: 10.1007/s11684-021-0911-0

Abstract: interference approaches revealed that the loss of GNAQ/11 palmitoylation substantially affected tumor cellproliferation and survival in UM cells.Importantly, the palmitoylation-deficient oncogenic GNAQ/11 failed to rescue the cell death initiatedsurvival and proliferation than other melanoma cells without GNAQ/11 mutations.strong>αq/11 downstream signaling by interfering with the MAPK pathway and BCL2 survival

Keywords： uveal melanoma     mutant GNAQ/11     palmitoylation     BCL2     combination target therapy    

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Different sites of extranodal involvement may affect the survival of patients with relapsed or refractorynon-Hodgkin lymphoma after chimeric antigen receptor T cell therapy

Lili Zhou, Ping Li, Shiguang Ye, Xiaochen Tang, Junbang Wang, Jie Liu, Aibin Liang

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 786-791 doi: 10.1007/s11684-020-0751-3

Abstract: associated with complete and durable remissions after anti-CD19 chimeric antigen receptor T (CAR-T) cellthis study, we found that the different sites of extranodal involvement may affect response, overall survival(OS), and progression-free survival (PFS) in patients with r/r NHL treated with anti-CD19 CAR-T cellssignificantly and negatively affected OS and PFS in patients with r/r NHL treated with anti-CD19 CAR-T cellThus, anti-CD19 CAR-T cell therapy may improve the prognosis of patients with BM infiltration.

Keywords： anti-CD19 chimeric antigen receptor T cell     soft tissue     bone marrow     relapsed or refractory non-Hodgkin    

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Construction of an immortalized neural progenitor cell strain and analysis of its immunogenicity

AN Ke, XU Ying, TIAN Xuebi, GAO Feng, TIAN Yuke, YANG Hui, ZHANG Chuanhan

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 63-69 doi: 10.1007/s11684-008-0012-3

Abstract: Neural progenitor cells (NPC) are those that are the source of neural cells for cell transplantationHere we report that an immortalized neural progenitor cell strain, which we named as INPC, was successfullyINPC retained the biological characteristics of its original cells and provided a safe and reliable cellplatform for the treatment of central nervous system diseases and transgenic cell transplantation.The immortalized cells may show good long-term survival and do not elicit an acute immunological response

Keywords： immortalized     long-term survival     differentiation     capacity     genotype    

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combination with pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 610-617 doi: 10.1007/s11684-021-0827-8

Abstract: For the entire cohort of patients, the median OS was 33.3 months, and the 1-year and 2-year overall survivalWith increased toxicities, the addition of bevacizumab to PP does not improve the overall survival of

Keywords： bevacizumab     elderly patient     advanced non-small-cell lung cancer     overall survival     toxicity    

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Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted Cell Survival Factor that Review

Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin

Engineering 2023, Volume 20, Issue 1,   Pages 9-18 doi: 10.1016/j.eng.2022.05.014

Abstract: Its murine homologue, T-cell death-associated 51 (TDAG51) gene, was initially discovered forits role in activation-induced apoptosis in T-cell hybridomas.endoplasmic reticulum stress signaling pathways as a crucial mediator of apoptosis, autophagy, and cell

Keywords： ER-stress     Metabolism     Apoptosis     Cell survival     PHLDA1    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 41-51 doi: 10.1007/s11684-016-0429-z

Abstract: expression of MID2 mRNA and protein was significantly upregulated in breast cancer tissue and established cellanalyses indicated that high MID2 expression was an independent prognostic factor for poor overall survivalResults showed that siRNA silencing of MID2 expression significantly reduced MCF-7 and MDA-MB-231 cellproliferation in vitro and blocked the growth of MDA-MB-231 cell xenograft tumors in vivo (P&

Keywords： breast cancer     MID2     proliferation     overall survival     xenograft    

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Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 430-435 doi: 10.1007/s11684-010-0700-7

Abstract: The overall 1-, 3-, and 5-year cumulative survival rates of 139 patients were 40%, 6%, and 3%, respectively, and the median survival time (MST) was 279 days.The adjuvant therapy could not prolong the survival time and decrease the liver metastasis rate of thebypass operation and laparotomy group and nonsurgical group, the adjuvant therapy could improve the survivalof the patients significantly (<0.05); however, the survival rate was not significantly different

Keywords： pancreatic neoplasms     neoadjuvant therapy     survival    

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Multi-stage emergency medicine logistics system optimization based on survival probability

Ke WANG, Yixin LIANG, Lindu ZHAO

Frontiers of Engineering Management 2017, Volume 4, Issue 2,   Pages 221-228 doi: 10.15302/J-FEM-2017020

Abstract: Using sudden cardiac deaths as an example and maximizing survival rate as the goal, this paper studiesthe influence of multi-stage medical logistics system optimization on the survival rate of sudden illnessA distribution model of survival is built, drone and ambulance arrival probability over time are discussed, a formula is proposed for maximum possible survival rate based on the probability of emergency medicaldrones delivering medical equipment for first aid on-site in emergencies can significantly increase survival

Keywords： emergency medicine logistics     ambulance drone     survival probability     critical illness    

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Association between telomere length and survival in cancer patients: a meta-analysis and review of literature

Xinsen Xu,Kai Qu,Qing Pang,Zhixin Wang,Yanyan Zhou,Chang Liu

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 191-203 doi: 10.1007/s11684-016-0450-2

Abstract:

The relationship between telomere length and cancer survival has been widely studied.In conclusion, shortened telomere in peripheral blood and tumor tissue might indicate poor survival fortelomere length ratios of tumor tissue to adjacent normal mucosa, the lower ratio might indicate better survival

Keywords： telomere     survival     cancer     meta-analysis    

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Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 138-142 doi: 10.1007/s11684-013-0247-5

Abstract: study was to determine whether SIPA1 545 C>T polymorphism was associated with overall survivalSurvival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-MeierWe found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185Patients with SIPA1545 T/T genotype had a significantly worse overall survival (OS) than did patientsindicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have a poorer survival

Keywords： SIPA1     polymorphism     metastatic breast cancer     survival    

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Intracellular trehalose improves the survival of human red blood cells by freeze-drying

HE Hui, LIU Baolin, HUA Zezhao, LI Chuan, WU Zhengzheng

Frontiers in Energy 2007, Volume 1, Issue 1,   Pages 120-124 doi: 10.1007/s11708-007-0014-x

Abstract: The aim of this study was to investigate the effects of intracellular trehalose on the survival of red
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Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 183-190 doi: 10.1007/s11684-016-0440-4

Abstract: Correlation and survival analyses were conducted using the modules, and gene ontology (GO) enrichment

Keywords： hepatocellular carcinoma     coexpression     module     microarray     prognosis    

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Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal Signet Ring Cell Article

Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li

Engineering 2020, Volume 6, Issue 9,   Pages 1028-1034 doi: 10.1016/j.eng.2020.06.007

Abstract:

Gastric signet ring cell carcinoma (SRCC) and colorectal SRCC are the most aggressive histologicalanalyze the metastatic patterns of SRCC and further estimate its contribution to the cancer-specific survivalSurvival differences of patients with different metastatic sites were compared with a Kaplan–Meier

Keywords： SEER Program     Survival analysis     Signet ring cell carcinoma     Metastases     Colorectal cancer     Gastric cancer    

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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: Data were analyzed for response to treatment, progression-free survival (PFS), and overall survival (Our data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Science and Technology in Human's Living and Survival in the 21st Century

Jiang Zhenghua

Strategic Study of CAE 2002, Volume 4, Issue 4,   Pages 1-11

Abstract:

This article, from the angle of management, reviews the world history over the past century, studies the prospective progress in the new century, and discusses ways for promoting world peace and cooperation and realizing common development.

Keywords： 21st century     progress in science and technology     human's living and survival    

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Title Author Date Type Operation

Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Journal Article

Different sites of extranodal involvement may affect the survival of patients with relapsed or refractorynon-Hodgkin lymphoma after chimeric antigen receptor T cell therapy

Lili Zhou, Ping Li, Shiguang Ye, Xiaochen Tang, Junbang Wang, Jie Liu, Aibin Liang

Journal Article

Construction of an immortalized neural progenitor cell strain and analysis of its immunogenicity

AN Ke, XU Ying, TIAN Xuebi, GAO Feng, TIAN Yuke, YANG Hui, ZHANG Chuanhan

Journal Article

combination with pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell

Journal Article

Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted Cell Survival Factor that

Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Journal Article

Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

Journal Article

Multi-stage emergency medicine logistics system optimization based on survival probability

Ke WANG, Yixin LIANG, Lindu ZHAO

Journal Article

Association between telomere length and survival in cancer patients: a meta-analysis and review of literature

Xinsen Xu,Kai Qu,Qing Pang,Zhixin Wang,Yanyan Zhou,Chang Liu

Journal Article

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Journal Article

Intracellular trehalose improves the survival of human red blood cells by freeze-drying

HE Hui, LIU Baolin, HUA Zezhao, LI Chuan, WU Zhengzheng

Journal Article

Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Journal Article

Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal Signet Ring Cell

Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li

Journal Article

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Journal Article

Science and Technology in Human's Living and Survival in the 21st Century

Jiang Zhenghua

Journal Article